Antibiotic tricks a switch

Old dogs: new tricks, old tricks, or no tricks.

tively referred to as “old dogs.” In some instances, the designation may be a term of endearment: in others, a term of derision. Virtually every chairperson must face the dilemma of dealing with these senior staff members. His or her decision will be based primarily on how productive the senior radiologist is. I have had the unique opportunity to practice radiology over the past 27 years in bot...

New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics.

Despite the availability of Mycobacterium tuberculosis (Mtb) drugs for over 50 years, tuberculosis (TB) remains at pandemic levels. New drugs are urgently needed for resistant strains, shortening duration of treatment, and targeting different stages of the disease, especially for treatment during human immunodeficiency virus co-infection. One solution to the conundrum that antibiotics kill the ...

Pain Tricks

A Bistable Gene Switch for Antibiotic Biosynthesis: The Butyrolactone Regulon in Streptomyces coelicolor

Many microorganisms, including bacteria of the class Streptomycetes, produce various secondary metabolites including antibiotics to gain a competitive advantage in their natural habitat. The production of these compounds is highly coordinated in a population to expedite accumulation to an effective concentration. Furthermore, as antibiotics are often toxic even to their producers, a coordinated...

Tips & tricks : Consider a fellowship Lesley

New hires, old problems 8 Good eats in Washington, DC 2 Inside this issue: President's message Amanda Roberts Based upon the overwhelming desire of NMRTers to write for publication, we decided to try something different in this year's print edition of Footnotes. Normally, you might find various NMRT announcements in the May issue, but this year we decided to add more thought-provoking articles,...